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KMID : 0360419680040010033
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Korean Journal of Pharmacology
1968 Volume.4 No. 1 p.33 ~ p.36
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The Effect of Atractylis Alkaloid on Schedule -Controlled Behavior
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Abstract
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The effect on schedule controlled behavior and toxicity of Atractylis alkaloid was investigated in the pigeons which were trained on a multiple fixed-ratio fixed-interval schedule of food presentation.
Atractylis alkaloid decreased the rate of responding during both the fixed-interval and fixed ratio component of the schedule at 10 mg/kg. Further depression occurred at 30 mg/kg. This “flat dose-response curve for depression of conditioned behavior was typical of tranquilizers.
Conclusively it was suspected that Atractylis alkaloid had major tranquilizing activity.
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